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PUBLICATIONS
Selected publications:
2024
  • Richiardone E, Al Roumi R, Lardinois F, Giolito MV, Ambroise J, Boidot R, Drotleff B, Ghesquière B, Bellahcène A, Bardelli A, Arena S, Corbet C. MCT1-dependent lactate recycling is a metabolic vulnerability in colorectal cancer cells upon acquired resistance to anti-EGFR targeted therapy. Cancer Lett. 2024 Aug 28;598:217091. doi: 10.1016/j.canlet.2024.217091. PubMed
  • Derouane F, Desgres M, Moroni C, Ambroise J, Berlière M, Van Bockstal MR, Galant C, van Marcke C, Vara-Messler M, Hutten SJ, Jonkers J, Mourao L, Scheele CLGJ, Duhoux FP, Corbet C. Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers. Breast Cancer Res. 2024;26(29). doi: 10.1186/s13058-024-01788-8. PubMed
  • Aubert L, Bastien E, Renoult O, Guilbaud C, Özkan K, Brusa D, Bouzin C, Richiardone E, Richard C, Boidot R, Léonard D, Corbet C, Feron O. Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors. EMBO Rep. 2024 Feb 16. doi: 10.1038/s44319-024-00089-7. PubMed
  • La Vecchia S, Fontana S, Salaroglio IC, Anobile DP, Digiovanni S, Akman M, Jafari N, Godel M, Costamagna C, Corbet C, Kopecka J, Riganti C. Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy. Cancer Lett. 2024 Sep 6;604:217221. doi: 10.1016/j.canlet.2024.217221. PubMed ​
2023
  • Zaryouh H, De Pauw I, Baysal H, Melis J, Van den bossche V, ..., Corbet C, Peeters M, Vermorken JB, De Waele J, Lardon F, Wouters A. Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity. Cancer Drug Resist 2023;6:709-28. doi: 10.20517/cdr.2023.62. PubMed
  • Kerkhove L, Geirnaert F, Laraki Rifi A, Law KL, Gutiérrez A, Oudaert I, Corbet C, Gevaert T, Dufait I, De Ridder M. Repurposing sulfasalazine as a radiosensitizer in hypoxic human colorectal cancer. Cancers 2023 Apr 18;15(8):2363. doi: 10.3390/cancers15082363. PubMed
2022
  • Cappellesso F, Orban MP, Shirgaonkar N, ..., Corbet C, ..., Virga F, Mazzone M. Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nat Cancer 2022 Dec 15. doi: 10.1038/s43048-022-00470-2. PubMed
  • Richiardone E, Van den bossche V, Corbet C. Metabolic studies in organoids: current applications, opportunities and challenges. Organoids 2022 1(1), 85-105. doi:10.3390/organoids1010008. PubMed
  • Johanns M, Corbet C, Jacobs R, Drappier M, Bommer GT, Herinckx G, Vertommen D, Tajeddine N, Young D, Messens J, Feron O, Steinberg GR, Hue L, Rider MH. Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators. Biochem J. 2022 Jun 30;479(12):1317-1336. doi:10.1042/BCJ20220170. PubMed
  • Van den bossche V, Zaryouh H, Vara-Messler M, Vignau J, Machiels, JP, Wouters A, Schmitz S, Corbet C. Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine. Drug Resist Updat. 2022 Jan 25;60:100806. doi: 10.1016/j.drup.2022.100806. PubMed
2021
  • Gonçalves AC, Richiardone E, Jorge J, Polónia B, Xavier CPR, Salaroglio IC, Riganti C, Vasconcelos MH, Corbet C, Sarmento-Ribeiro AB. Impact of cancer metabolism on therapy resistance - Clinical implications. Drug Resist Updat. 2021 Dec:59:100797. doi: 10.1016/j.drup.2021.100797. PubMed
  • Dierge E, Debock E, Guilbaud C, Corbet C, Mignolet E, Mignard L, Bastien E, Dessy C, Larondelle Y, Feron O. Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects. Cell Metab. 2021 June 8:S1550-4131(21)00233-3. doi: 10.1016/j.cmet.2021.05.016. PubMed
  • Vander Linden C*, Corbet C*, Bastien E, Martherus R, Guilbaud C, Petit L, Wauthier L, Loriot A, De Smet C, Feron O. Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell Rep. 2021 June 21;35(9):109202. doi: 10.1016/j.celrep.2021.109202. PubMed *co-first authors
  • Virga F, Cappellesso F, Stijlemans B, ... Corbet C, Van Ginderachter JA, Ivan M, Taverna D, Mazzone M. Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation. Sci Adv. 2021 May 7;7(19):eabf0466. doi: 10.1126/sciadv.abf0466. PubMed

2020
  • Corbet C, Bastien E, Santiago de Jesus JP, Dierge E et al. TGFbeta2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. Nat. Commun. 2020 Jan 23;11(1):454. doi: 10.1038/s41467-019-14262-3. PubMed
  • Trempolec N, Degavre C, Doix B, Brusa D, Corbet C, Feron O. Acidosis-induced TGF-beta2 production promotes lipid droplet formation in dendritic cells and alters their potential to support anti-mesothelioma T cell response. Cancers. 2020 May 19;12(5):1284. doi:10.3390/cancers12051284. PubMed
  • Mignion L, Acciardo S, Gourgue F, Joudiou N, Caignet X, Goebbels RM, Corbet C, Feron O et al. Metabolic imaging using hyperpolarized pyruvate-lactate exchange assesses response or resistance to the EGFR inhibitor cetuximab in patient-derived HNSCC xenografts. Clin. Cancer Res. 2020 Apr 15;26(8):1932-1943. doi:10.1158/1078-0432.CCR-19-1369. PubMed
  • Vander Linden C. & Corbet C. Reconciling environment-mediated metabolic heterogeneity with the oncogene-driven cancer paradigm in precision oncology. Semin. Cell Dev. Biol. 2020 Feb;98:202-210. doi: 10.1016/j.semcdb.2019.05.016. PubMed​

2019
  • Strickaert A., Corbet C., Spinette SA. et al. Reprogramming of energetic metabolism: increased expression and roles of pyruvate carboxylase in papillary thyroid cancer. Thyroid. 2019 Apr 16. doi: 10.1089/thy.2018.0435. PubMed
  • Vander Linden C. & Corbet C. Therapeutic targeting of cancer stem cells: integrating and exploiting the acidic niche. Front. Oncol. 2019 Mar 19;9:159. doi: 10.3389/fonc.2019.00159. PubMed
  • Wang H., Jiang H., Corbet C., de Mey S. et al. Piperlongumine increases senitivity of colorectal cancer cells to radiation: involvement of ROS production via dual inhibition of glutathione and thioredoxin systems. Cancer Lett. 2019 May 28;450:42-50. doi: 10.1016/j.canlet.2019.02.034. PubMed
  • Lévêque R., Corbet C., Aubert L., Guilbert M. et al. ProNGF increases breast tumor aggressiveness through functional association of TrkA with EphA2. Cancer Lett. 2019 May 1;449:196-206. doi: 10.1016/j.canlet.2019.02.019. PubMed
  • Spillier Q., Vertommen D., Ravez S., Marteau R., Thémans Q., Corbet C., Feron O. et al. Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. Sci. Rep. 2019 Mar 18;9(1):4737. doi: 10.1038/s41598-019-41187-0. PubMed

2018
  • Corbet C., Bastien E., ​Draoui N., Doix B., Mignion L., Jordan B.F. et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018 Mar 23;9(1):1208. doi: 10.1038/s41467-018-03525-0. PubMed
  • Corbet C. Stem cell metabolism in cancer and healthy tissues: pyruvate in the limelight. Front Pharmacol. 2018 Jan 4;8:958. doi: 10.3389/fphar.2017.00958. PubMed

2017
  • Corbet C. & Feron O. Tumour acidosis: from the passenger to the driver's seat. Nat Rev Cancer 2017 Oct;17(10):577-593. doi: 10.1038/nrc.2017.77. PubMed
  • Corbet C. & Feron O. Emerging roles of lipid metabolism in cancer progression. Curr Opin Clin Nutr Metab Care. 2017 Jul;20(4):254-260. doi: 10.1097/MCO.0000000000000381. PubMed
  • Corbet C. & Feron O. Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling. Biochim Biophys Acta. Reviews on Cancer. 2017 Aug;1868(1):7-15. doi: 10.1016/j.bbcan.2017.01.002. PubMed
 
2016
  • Corbet C., Pinto A., Martherus R., Santiago de Jesus J.P., Polet F., Feron O. Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation. Cell Metab. 2016 Aug;24(2):311-23. doi: 10.1016/j.cmet.2016.07.003. PubMed
  • Corbet C., Ragelle H., Pourcelle V., Vanvarenberg K., Marchand-Brynaert J., Préat V., Feron O. Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method. J Control Release. 2016 Feb;223:53-63. doi: 10.1016/j.jconrel.2015.12.020. PubMed

​All publications of our lab on PubMed